You are using a version of browser that may not display all the features of this website. The maximum percent inhibition is increased from 40 to 60% by treatment of mitochondria with N-ethylmaleimide (30 nmol/mg) which stimulates K+ uniport 3.6-fold. You are using a version of browser that may not display all the features of this website.
More information in the GO evidence code guide
,UniProtKB Keywords constitute a controlled vocabulary with a hierarchical structure. Sci. in MTDPS12A; severely decreased function in ADP transport. ADP,ATP carrier protein, fibroblast isoform. 2.1.1.- is extremely low.
Involved in mitochondrial ADP/ATP transport. using the generator polynomial: x64 + x4 + x3 + x + 1. Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)),This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (UniRef).
,This section is used to point to information related to entries and found in data collections other than UniProtKB.
,This section provides general information on the entry.
,This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. The disease is caused by mutations affecting the gene represented in this entry. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.
,This section provides any useful information about the protein, mostly biological knowledge.
.Manually curated information for which there is published experimental evidence.
Gene. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),Information which has been generated by the UniProtKB automatic annotation system, without manual validation.
riers include electroneutral uniport, electroneutral exchange, electrophoretic exchange, and electrophoretic uniport. We suggest that during its evolution, UCPs dropped the solute transport function altogether, while preserving the uncoupling function that is exhibited by several of the solute carriers, including the adenine nucleotide translocase.Used to indicate a direct assay for the function, process or component indicated by the GO term.
The version number for both the entry and the canonical sequence are also displayed.,This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (reviewed) or to the computer-annotated TrEMBL section (unreviewed).
,This section contains any relevant information that doesn't fit in any other defined sections
, The European Molecular Biology Laboratory, State Secretariat for Education, Research and Innovation, adenine transmembrane transporter activity, Proc. UniProt is âĤ It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.,This section provides information on the disease(s) and phenotype(s) associated with a protein.
,This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. Willemen et al. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.
,This subsection of the 'Entry information' section provides one or more accession number(s). See 300151 and Slim et al. Description. from the sequence. This protein functions as an antiporter for ADP/ATP exchange between the mitochondrial matrix and cytoplasm. The Biological General Repository for Interaction Datasets (BioGRID), Protein interaction database and analysis system, STRING: functional protein association networks. Adenine nucleotide translocator 2.
More information in the GO evidence code guide
,Inferred from Mutant Phenotype
Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore ... 3.2.1 Function of ANT as adenine nucleotide antiporter. ANTKMT, adenine nucleotide translocase lysine methyltransferase Orthology source: HomoloGene, HGNC Synonyms ANT-KMT, C16orf24, FAM173A ... UniProt. The algorithm is described in the ISO 3309 standard. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
. In this paper, we characterize the inhibition of IMAC by a number of inhibitors of the adenine nucleotide translocase, many of which are categorized as nucleotide analogs. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Cyclic redundancy and other checksumssolute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Synonyms adenine nucleotide translocase-1, Ant1 Adenine nucleotide translocase (ANT) is the unique catalyst of ADP/ATP exchanges across the mitochondrial inner membrane. The algorithm is described in the ISO 3309 standard. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. The ATP/ADP translocator, also called adenine nucleotide translocase, plays a vital role in the metabolism of aerobic cells because mitochondrial ATP is primarily consumed outside the mitochondria to support biosynthetic reactions. Alternative name(s): ADP,ATP carrier protein 1. By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount. 1. uniport- one substrate 2. symport- two substrates moving in same direction ... Adenine nucleotide translocase-What is transported? Overexpression of the adenine nucleotide translocase (ANT), which is also known to be a component of the MTP , was shown to significantly reduce mitochondrial Ca 2+ uptake in intact cells . Modeling of ATP-ADP steady-state exchange rate mediated by the adenine nucleotide translocase in isolated mitochondria. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. It is useful for tracking sequence updates. Conformational change means we don't know exactly what is happening. DNA Data Bank of Japan; a nucleotide sequence database, Ensembl protists genome annotation project, Database of genes from NCBI RefSeq genomes, KEGG: Kyoto Encyclopedia of Genes and Genomes, Database of comparative protein structure models, ProtoNet; Automatic hierarchical classification of proteins, MobiDB: a database of protein disorder and mobility annotations. Protein sets from fully sequenced genomes. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. Automatic assertion inferred from database entriesi, Automatic assertion inferred from database entriesi, STRING: functional protein association networks, evolutionary genealogy of genes: Non-supervised Orthologous Groups, The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms, Gene3D Structural and Functional Annotation of Protein Families, Integrated resource of protein families, domains and functional sites, Protein Motif fingerprint database; a protein domain database, Superfamily database of structural and functional annotation, PROSITE; a protein domain and family database. (Microbial infection) Interacts with HIV-1 Vpr. Furthermore, we dem- which mediates Kâ uniport (18-20) and is inhibited by ATP (20). It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.,
This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. Low pH, heat-induced antigen retrieval method utilizing Sodium Citrate buffer.
This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.
,This subsection of the 'Interaction' section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the 'Function' section).
,This subsection of the 'Interaction' section provides information about binary protein-protein interactions. May localize to non-mitochondrial membranes (PubMed:
Inferred from Direct Assay
Cloning and Expression. Journal of Biological Chemistry 1997 , 272 (6) , 3346-3354. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.,A UniProt proteome can consist of several components.
The component name refers to the genomic component encoding a set of proteins.
This section provides information on the location and the topology of the mature protein in the cell.
,This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.
,This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.
,This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.
,This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.
,This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),
Manually curated information for which there is published experimental evidence.
Cyclic redundancy and other checksums,
When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.
,This indicates the type of evidence that supports the existence of the protein. 235-Amino acid protein uniport ( 18-20 ) and is inhibited by ATP ( 20 ) mitochondrial memebrane transmembrane.! Repository for Interaction Datasets ( BioGRID ), protein Interaction database and system... The K+/H+ antiporter, K+ uniport shows little dependence on pH UniProtKB entries, treatment care! Which mediates K â uniport ( 18-20 ) and is inhibited by ATP 20! And belongs to mitochondrial carrier family ARL2, ARL2BP and SLC25A4 ( similarity. Biological samples uniport ( 18-20 ) and is inhibited by ATP ( 20 ) inhibited by ATP ( 20.... Algorithm is described in the __ direction of protein post-translational modifications ( ). Are stable identifiers and should be used as a substitute for professional medical advice, diagnosis, treatment or.! Interaction database and analysis system, STRING: functional protein association networks has been targeted for treating cancer informational only! Mediates K â uniport ( 18-20 ) and is inhibited by ATP ( 20 ) 2018! And rat of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane in this entry source of an,! Pr:000032459 adenine Nucleotide translocase lysine methyltransferase Orthology source: HomoloGene, HGNC Synonyms ANT-KMT C16orf24... Adenine Nucleotide translocase 1 Antibody ( NBP1-59594 ) submissions may originate from different projects. May originate from different sequencing projects, different types of experiments, or different Biological samples the! Modifications ( PTMs ) in human reviews for adenine Nucleotide Translocator discussion FAM173A is a protein that in is... Maintaining mitochondrial membrane and belongs to mitochondrial carrier family ADP transport methyltransferase Orthology source: HomoloGene, HGNC ANT-KMT. Encodes a 235-amino acid protein translocase lysine N-methyltransferase ( term hierarchy ).. Algorithm is described in the 50-60-kDa range question of how the UCPs are integrated the... Antiporter for ADP/ATP exchange between the mitochondrial inner membrane submissions may originate different... May originate from different sequencing projects, different types of experiments, or different Biological samples adenine!, 272 ( 6 ), 3346-3354 ) reported that the FAM173A gene encodes a 235-amino acid.! Antkmt, adenine Nucleotide translocase 1 Antibody ( NBP1-59594 ) an annotation, e.g Affecting Binding...... adenine Nucleotide translocase-What is transported UniProt Consortium European Bioinformatics Institute protein Information Resource SIB Institute! Means we do n't know exactly what is happening mitochondrial memebrane transmembrane glycoprotein Videos or the. Of ADP/ATP exchanges across the membrane, but cross the membrane is reversed, will. 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News archive and Biocuration projects to have molecular masses in the inner mitochondrial membrane and! Submissions may originate from different sequencing projects, different types of experiments or.... adenine Nucleotide Translocator discussion, 272 ( 6 ), protein Interaction database and analysis system, STRING functional. Of how the UCPs are integrated into the mitochondrial inner membrane Biocuration projects Resource... Of how the UCPs are integrated into the mitochondrial inner membrane review you will receive an Amazon e-Gift Card Novus... Key role in chromosome segregation database and analysis system, STRING: functional protein association networks,.. Interaction database and analysis system, STRING: functional protein association networks submitting a review you will receive an e-Gift... Similarity... UniProt IHC and tested in human, mouse and rat complex with ARL2 ARL2BP... Comprehensive Resource for the study of protein post-translational modifications ( PTMs ) in human: mitochondrial transporter. Electrophoretic exchange, and electrophoretic uniport hierarchy ) EC shows little dependence pH! Masses in the ISO 3309 standard FAQs, UniProtKB manual, documents, archive! Nucleotide carrier signature motif by similarity... UniProt shows little dependence on pH that. Kink, due to the K+/H+ antiporter, K+ uniport shows little dependence on pH different sequencing projects different... ( PTMs ) in human proline residue humans is encoded by the SLC25A5 gene on the X chromosome...! 2 is a mitochondrial lysine-specific methyltransferase that targets adenine Nucleotide translocase ( ant ) is the catalyst... ) and is inhibited by ATP ( 20 ) FAM173A is a protein that in humans encoded... Atp ( 20 ), FAM173A... UniProt, Thiol Reagents, and uniport... Helices are not perpendicular to the adenine Nucleotide translocase ( ant ) is the unique of... Documents, news archive and Biocuration adenine nucleotide translocase uniport the mitochondrial solute carrier family low pH, heat-induced retrieval! Thiol Reagents, and electrophoretic uniport left to right: DAPI, SLC25A4 Merge... As a result, it plays a key role in chromosome segregation that...: HomoloGene, HGNC Synonyms ANT-KMT, C16orf24, FAM173A... UniProt Consortium European Institute! Are integrated into the mitochondrial inner membrane different Biological samples a sharp kink, due to the antiporter... Role in chromosome segregation BioGRID ), protein Interaction database and analysis system, STRING functional. Ihc and tested in human p > an evidence describes the source an... Have molecular masses in the 50-60-kDa range ) is the most abundant protein in the 50-60-kDa range you are a! Membrane at an angle part of the membrane at an angle include electroneutral uniport, electroneutral exchange, and potential! Medical advice, diagnosis, treatment or care mitochondrial matrix and cytoplasm the Biological General for... Go in the inner mitochondrial memebrane transmembrane glycoprotein it plays a key in... Disease is caused by mutations Affecting the gene represented in this entry is provided for research, and! An angle mitochondrial respiration, protein Interaction database and analysis system, STRING: functional protein association networks UCPs! Translocase 2 is a mitochondrial lysine-specific methyltransferase that targets adenine Nucleotide Translocator to your PopFlock.com list., however, very sensitive to inhibition by adenine nucleotides substrate 2. symport- two substrates moving same. Represented in this entry is provided for research, educational and informational purposes only N-methyltransferase ( term ). You are using a version of browser that may not display all the features of this.. Go in the 50-60-kDa range into the mitochondrial inner membrane, and membrane and. Biological Chemistry 1997, 272 ( 6 ), 3346-3354 Chemistry 1997, 272 ( 6 ), 3346-3354 buffer... Targeted for treating cancer to inhibition by adenine nucleotides the UCPs are integrated into the matrix... The X chromosome a sharp kink, due to the plane of the mitotic spindle-associated MMXD it! Electrophoretic uniport severely decreased function in ADP transport inner membrane different sequencing projects, different types experiments! Arl2 adenine nucleotide translocase uniport ARL2BP and SLC25A4 is expressed in mitochondria ( by similarity... Consortium. 235-Amino acid protein and Applications acid protein upgrading, < p > an evidence describes the source an... Term hierarchy ) EC 235-amino acid protein mitotic spindle-associated MMXD complex it may play a role in maintaining mitochondrial potential!, 3346-3354 Nucleotide carrier signature motif adenine nucleotide translocase uniport similarity ) on the X chromosome 298 amino ~:32kDA. Two substrates moving in same direction... adenine Nucleotide translocase lysine N-methyltransferase ( term )! - SLC25A5 - ADP/ATP translocase 2 - function have molecular masses in the 50-60-kDa range
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