Diese Seite wurde zuletzt am 20. Copyright © 2021 Elsevier B.V. or its licensors or contributors. J. Biol. Electron transfer flavoprotein is involved in the process by which fats and proteins are broken down to produce energy. Durch den oben genannten Mechanismus gelangen diese Elektronen zur Atmungskette. Electron-transfer flavoprotein-ubiquinone oxidoreductase (ETF-QO) was purified to homogeneity from pig liver submitochondrial particles. In the complex, electron density for the FAD domain of ETF is absent, indicating high mobility. The ETFA gene provides instructions for making one part (the alpha subunit) of an enzyme called electron transfer flavoprotein. When an acyl-CoA dehydrogenase family … Studies on the mechanism of electron bifurcation catalyzed by electron transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) of Acidaminococcus fermentans. Für alle Bedeutungen von ETF klicken Sie bitte auf "Mehr". These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. This process is experimental and the keywords may be updated as the learning algorithm improves. View article PMID: 10026281 ETFB - Electron Transferring Flavoprotein, Beta Polypeptide. Electron Transfer Flavoproteins. It catalyzes ubiquinone (UQ) reduction by ETF, linking oxidation of fatty acids and some amino acids to the mitochondrial respiratory chain. Bitte scrollen Sie nach unten und klicken Sie, um jeden von ihnen zu sehen. 2014; 289:5145–5157. ETF-QO is very highly conserved in evolution and the recombinant enzyme from the bacterium Rhodobacter sphaeroides has allowed the mutational analysis of a number of residues that the structure suggested are involved in modulating the reduction potential of the cofactors. Dieses wird wieder zu FADH2 reduziert und gibt nun seinerseits die Elektronen an das in der mitochondrialen Innenmembran lokalisierte Ubichinon ab. Copyright © 2010 Elsevier B.V. All rights reserved. Sie sind auf der linken Seite unten aufgeführt. Das Heterodimer aus ETF-α und ETF-β ist dort für den Transport zweier Elektronen, welche durch FADH2 zur Verfügung gestellt werden, verantwortlich. Electron-transferring flavoprotein (ETF) from the anaerobic bacterium Megasphaera elsdenii is a heterodimer containing two FAD cofactors. Electron transfer flavoprotein:ubiqionone oxidoreductase (ETF-QO) is a component of the mitochondrial respiratory chain that together with electron transfer flavoprotein (ETF) forms a short pathway that transfers electrons from 11 different mitochondrial flavoprotein dehydrogenases to the ubiquinone pool. The Iron−Sulfur Cluster of Electron Transfer Flavoprotein−Ubiquinone Oxidoreductase Is the Electron Acceptor for Electron Transfer Flavoprotein. Electron Transferring Flavoprotein, Beta Polypeptide - How is Electron Transferring Flavoprotein, Beta Polypeptide abbreviated? Electron transferring flavoprotein listed as ETF. IDs. Zahlreiche mitochondriale Enzyme beinhalten Flavinadenindinukleotid als kovalent gebundenes Coenzym. The X-ray structure of the pig liver enzyme has been solved in the presence and absence of a bound ubiquinone. This enzyme is normally active in the mitochondria, the energy-producing centers in cells. ETF - Electron transferring flavoprotein. Electron-transferring-flavoprotein dehydrogenase is an enzyme that transfers electrons from electron-transferring flavoprotein in the mitochondrial matrix, to the ubiquinone pool in the inner mitochondrial membrane. ETF … Two transcript variants encoding different isoforms have been found for this gene. It is comparable in molecular weight and general properties to ETF-QO from beef heart [Ruzicka, F. J., & Beinert, H. (1977) J. Biol. Please wait a moment until all data is loaded. [1] [2] It is part of the electron transport chain. https://doi.org/10.1021/bi800507p Robert J. Usselman,, Alistair J. Fielding,, Frank E. Frerman,, Nicholas … electron-transferring-flavoprotein dehydrogenase activity Source: UniProtKB "Expression of human electron transfer flavoprotein-ubiquinone oxidoreductase from a baculovirus vector: kinetic and spectral characterization of the human protein." Das Heterodimer aus ETF-α und ETF-β ist dort für den Transport zweier Elektronen, welche durch FADH2 zur Verfügung gestellt werden, verantwortlich. ►Structural and mutagenesis studies suggest that FAD is the electron donor to ubiquinone (UQ). 86551-03-3. T1 - Defining electron bifurcation in the electron-transferring flavoprotein family. It is Electron Transferring Flavoprotein, Beta Polypeptide. Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial. By this pathway, energy from fat and amino acid oxidation can be used to generate protonmotive force and contribute to … Information on EC 1.5.5.1 - electron-transferring-flavoprotein dehydrogenase for references in articles please use BRENDA:EC1.5.5.1. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Deficiencies in ETF or ETF-QO result in multiple acyl-CoA dehydrogenase deficiency, a human metabolic disease. Flavoproteins that serve as specific electron acceptors for a variety of DEHYDROGENASES. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Cite this entry as: (2013) Electron Transferring Flavoprotein. ETF - Electron transferring flavoprotein. The gene deficiencies have been implicated in type II glutaricaciduria. Here, we describe pathogenic mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene in seven patients from five independent families fulfilling the clinical, histological and biochemical criteria of the myopathic form of coenzyme Q10 deficiency. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Health Conditions Related to Genetic Changes. Neben Electron Transfer Flavoprotein hat ETF andere Bedeutungen. Biochemistry 38, 1977-89, (1999). Das Elektronentransferierende Flavoprotein (abgekürzt ETF) ist ein Komplex aus zwei Proteinketten, der in Bakterien und Eukaryoten Teil der Atmungskette ist. 252, 8440-8445], and the electron spin resonance signals of the reduced iron-sulfur cluster are essentially identical. IDs. This is a preview … Electron transfer flavoprotein dehydrogenase is involved in the process by which fats and proteins are broken down to produce energy. Electron Transferring Flavoprotein, Beta Polypeptide listed as ETFB. This message will disappear when all data is loaded. This enzyme is normally active in the mitochondria, the energy-producing centers in cells. electron transferring flavoprotein complex was observed, providing the first direct observation of these mammalian complexes. Reviewed-Annotation score: -Experimental evidence at protein level i. This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The enzyme is found in both prokaryotes and eukaryotes and contains a flavin and FE-S cluster. Accepts electrons from ETF and reduces ubiquinone. N-terminal sequencing identified the α-subunits (40 kDa) as butyryl-CoA dehydrogenase (Bcd) and the β-subunit (36 kDa) and γ-subunit (28 kDa) as the subunits of an electron-transferring flavoprotein (Etf). ETF fungiert hier als Elektronentransporter. electron transfer flavoprotein-ubiquinone oxidoreductase. Energy Conservation via Electron-Transferring Flavoprotein in Anaerobic Bacteria Gloria Herrmann, Elamparithi Jayamani, Galina Mai, and Wolfgang Buckel* Laboratorium fu¨r Mikrobiologie, Fachbereich Biologie, Philipps-Universita¨t, 35032 Marburg, Germany Energy conservation in … Groen and J.A. Electron transfer flavoproteins are dimeric proteins that function as mobile electron carriers. The electron-transferring flavoprotein activity, purified 22-fold, was separated into two major flavoprotein components, A and B, after polyacrylamide gel electrophoresis. ETFB - Electron Transferring Flavoprotein, Beta Polypeptide. Looking for abbreviations of ETFB? Electron Transferring Flavoprotein, Beta Polypeptide listed as ETFB. Hitherto, electron transfer (ET) between redox proteins has been deemed to occur via donor–acceptor binding, and diffusible reactive species are considered as deleterious side-products in such systems. The latter reaction is inhibited by rotenone and carbonyl cyanide … [1] [2] It is part of the electron transport chain. Electron transfer flavoprotein:ubiqionone oxidoreductase (ETF-QO) is a component of the mitochondrial respiratory chain that together with electron transfer flavoprotein (ETF) forms a short pathway that transfers electrons from 11 different mitochondrial flavoprotein dehydrogenases to the ubiquinone pool. An electron transfer flavoprotein (ETF) or electron transfer flavoprotein complex (CETF) is a flavoprotein located on the matrix face of the inner mitochondrial membrane and functions as a specific electron acceptor for primary dehydrogenases, transferring the electrons to terminal respiratory systems such as electron-transferring-flavoprotein dehydrogenase. Bifurcation catalyzed by electron transferring flavoprotein ( abgekürzt ETF ) ist ein Komplex aus zwei Proteinketten, der Bakterien... Um alle Funktionen in diesem Shop nutzen zu können und Eukaryoten Teil Atmungskette. Visualized, downloaded, and analyzed by users who range from students to specialized scientists oxidoreductase transfers... Central metabolism with the respiratory chain via ETF-ubiquinone oxidoreductase ( ETF-QO ) is a Heterodimer containing two cofactors. Denitrificans electron transfer flavoprotein dehydrogenase is involved in the process by which fats and proteins broken... 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